Computational Biology Research Group University of Oxford
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Welcome to the CBRG

The Computational Biology Research Group (CBRG) provides computing support for bioinformatics analysis at the University of Oxford. We have expertise in many aspects of bioinformatics (sequence analysis, microarrays, proteomics and integration). We especially encourage collaborations that require writing custom software, bioinformatics tools and databases.

An account with the CBRG has many benefits and gives automatic access to a large number of molecular biology computing packages and to numerous biological databases.

We are based at the Sir William Dunn School of Pathology and at the Weatherall Institute of Molecular Medicine. Full details can be found on the contact details page.


Bioinformatics analysis tools online:

A wide range of bioinformatics programs are available online via EMBOSS Explorer.
You will need a molbiol username and password to use these tools.

Other web tools available include: BLAST, MIG, MASCOT and CRISPRscreen   (see full list).



Recent Papers:


------------ 2014

Clynes D, Jelinska C, Xella B, Ayyub H, Taylor S, Mitson M, Bachrati CZ, Higgs DR, Gibbons RJ
ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells.
PLoS One (2014) 9: e92915
  » View abstract

Hay AS, Pieper B, Cooke E, Mandáková T, Cartolano M, Tattersall AD, Ioio RD, McGowan SJ, Barkoulas M, Galinha C, Rast MI, Hofhuis H, Then C, Plieske J, Ganal M, Mott R, Martinez-Garcia JF, Carine MA, Scotland RW, Gan X, Filatov DA, Lysak MA, Tsiantis M
Cardamine hirsuta: a versatile genetic system for comparative studies.
Plant J (2014) 78: 1-15
  » View abstract

Gutowska-Owsiak D, Selvakumar TA, Salimi M, Taylor S, Ogg GS
Histamine enhances keratinocyte-mediated resolution of inflammation by promoting wound healing and response to infection.
Clin Exp Dermatol (2014) 39: 187-95
  » View abstract

Hughes JR, Roberts N, McGowan S, Hay D, Giannoulatou E, Lynch M, De Gobbi M, Taylor S, Gibbons R, Higgs DR
Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.
Nat Genet (2014) 46: 205-12
  » View abstract

Favaro FP, Alvizi L, Zechi-Ceide RM, Bertola D, Felix TM, de Souza J, Raskin S, Twigg SR, Weiner AM, Armas P, Margarit E, Calcaterra NB, Andersen GR, McGowan SJ, Wilkie AO, Richieri-Costa A, de Almeida ML, Passos-Bueno MR
A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects.
Am J Hum Genet (2014) 94: 120-8
  » View abstract

Pan X, Huang LC, Dong T, Peng Y, Cerundolo V, McGowan S, Ogg G
Combinatorial HLA-peptide bead libraries for high throughput identification of CD8⁺ T cell specificity.
J Immunol Methods (2014) 403: 72-8
  » View abstract


------------ 2013

Swiers G, Baumann C, O'Rourke J, Giannoulatou E, Taylor S, Joshi A, Moignard V, Pina C, Bee T, Kokkaliaris KD, Yoshimoto M, Yoder MC, Frampton J, Schroeder T, Enver T, Göttgens B, de Bruijn MF
Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level.
Nat Commun (2013) 4: 2924
  » View abstract

Giannoulatou E, McVean G, Taylor IB, McGowan SJ, Maher GJ, Iqbal Z, Pfeifer SP, Turner I, Burkitt Wright EM, Shorto J, Itani A, Turner K, Gregory L, Buck D, Rajpert-De Meyts E, Looijenga LH, Kerr B, Wilkie AO, Goriely A
Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.
Proc Natl Acad Sci U S A (2013) 110: 20152-7
  » View abstract

Salek M, McGowan S, Trudgian DC, Dushek O, de Wet B, Efstathiou G, Acuto O
Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.
PLoS One (2013) 8: e77423
  » View abstract

May G, Soneji S, Tipping AJ, Teles J, McGowan SJ, Wu M, Guo Y, Fugazza C, Brown J, Karlsson G, Pina C, Olariu V, Taylor S, Tenen DG, Peterson C, Enver T
Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.
Cell Stem Cell (2013) 13: 754-68
  » View abstract

Roberts I, Alford K, Hall G, Juban G, Richmond H, Norton A, Vallance G, Perkins K, Marchi E, McGowan S, Roy A, Cowan G, Anthony M, Gupta A, Ho J, Uthaya S, Curley A, Rasiah SV, Watts T, Nicholl R, Bedford-Russell A, Blumberg R, Thomas A, Gibson B, Halsey C, Lee PW, Godambe S, Sweeney C, Bhatnagar N, Goriely A, Campbell P, Vyas P
GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.
Blood (2013) 122: 3908-17
  » View abstract

Brackley CA, Taylor S, Papantonis A, Cook PR, Marenduzzo D
Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization.
Proc Natl Acad Sci U S A (2013) 110: E3605-11
  » View abstract

McGowan SJ, Hughes JR, Han ZP, Taylor S
MIG: Multi-Image Genome viewer.
Bioinformatics (2013) 29: 2477-8
  » View abstract

Babbs C, Roberts NA, Sanchez-Pulido L, McGowan SJ, Ahmed MR, Brown JM, Sabry MA, Bentley DR, McVean GA, Donnelly P, Gileadi O, Ponting CP, Higgs DR, Buckle VJ
Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I.
Haematologica (2013) 98: 1383-7
  » View abstract

Hughes JR, Lower KM, Dunham I, Taylor S, De Gobbi M, Sloane-Stanley JA, McGowan S, Ragoussis J, Vernimmen D, Gibbons RJ, Higgs DR
High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
Philos Trans R Soc Lond B Biol Sci (2013) 368: 20120361
  » View abstract



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This file last modified Thursday February 06, 2014