Welcome to the CBRG

The Computational Biology Research Group (CBRG) provides computing support for bioinformatics analysis at the University of Oxford. We have expertise in many aspects of bioinformatics (sequence analysis, microarrays, proteomics and integration). We especially encourage collaborations that require writing custom software, bioinformatics tools and databases.

An account with the CBRG has many benefits and gives automatic access to a large number of molecular biology computing packages and to numerous biological databases.

We are based at the Sir William Dunn School of Pathology and at the Weatherall Institute of Molecular Medicine. Full details can be found on the contact details page.

Recent Papers:

2012

Malavige GN, McGowan S, Atukorale V, Salimi M, Peelawatta M, Fernando N, Jayaratne SD, Ogg G
Identification of serotype-specific T cell responses to highly conserved regions of the dengue viruses.
Clin Exp Immunol. (2012) 168: 215-223

Blais M, Zhang Y, Rostron T, Griffin H, Taylor S, Xu K, Yan H, Wu H, James I, John M, Dong T, Rowland-Jones S
High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism
J Immunol. (2012) 188: 4663-4670

Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J, Bezstarosti K, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkinsend S, Brockdorff N
RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
Cell. (2012) 148(4): 664-678

Kowalczyk M, Hughes J, Garrick D, Lynch M, Sharpe J, Sloane-Stanley J, McGowan S, De Gobbi M, Hosseini M, Vernimmen D, Brown J, Gray N, Collavin L, Gibbons R, Flint J, Taylor S, Buckle V, Milne T, Wood W, Higgs D
Intragenic enhancers act as alternative promoters
Mol Cell. (2012) 45(4): 447-458

Gutowska-Owsiak D, Schaupp A, Salimi M, Tharini A, McPherson T, Taylor S, Ogg G
IL-17 down regulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion
Exp Dermatol. (2012) 21(2): 104-110

2011

De Gobbi M, Garrick D, Lynch M, Vernimmen D, Hughes J, Nicolas G, Luc S, Lower K, Sloane-Stanley J, Pina C, Soneji S, Renella R, Taylor S, Jacobsen S, Vyas P, Gibbons R and Higgs D
Generation of Bivalent Chromatin Domains During Cell Fate Decisions
Epigenetics Chromatin. (2011) 4(1): 9

Roy N, Myerson S, Patel R, Schuh A, Wainscoat J, McGowan S, Marchi E, Atoyebi E, Littlewood T, Chacko J, Vyas P and Killick S
Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes
Br J Haematol. (2011) 154(4): 521-524

Gutowska-Owsiak D, Schaupp A, Salimi M, Taylor S, Ogg GS
IL-22 down-regulates filaggrin expression and affects expression of profilaggrin processing enzymes
Br J Dermatol. (2011) 165(3): 492-498

Chi J, Ballabio E, Chen X, Kusec R, Taylor S, Hay D, Tramonti D, Saunders N, Littlewood T, Pezzella F, Boultwood J, Wainscoat J, Hatton C, Lawrie C.
MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival
Biol Direct. (2011) 18: 23.

Simister P, Schaper F, O'Reilly N, McGowan S, Feller S
Self-organization and regulation of intrinsically disordered proteins with folded N-termini
PLoS Biol. (2011) 9(2): e1000591.

Slyker J, John-Stewart G, Dong T, Lohman-Payne B, Reilly M, Atzberger A, Taylor S, Maleche-Obimbo E, Mbori-Ngacha D, Rowland-Jones S
Phenotypic Characterization of HIV-Specific CD8 T Cells during Early and Chronic Infant HIV-1 Infection
PLoS ONE (2011) 6(5): e20375

Merryweather-Clarke A, Atzberger A, Soneji S, Gray N, Clark K, Waugh C, McGowan S, Taylor S, Nandi A, Wood W, Roberts D, Higgs D, Buckle V, and Robson K
Global gene expression analysis of human erythroid progenitors
Blood (2011) 117(13): e96-e108

Brockmeyer C, Paster W, Pepper D, Tan C, Trudgian D, McGowan S, Fu G, Gascoigne N, Acuto O, Salek M
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies themis as a new TCR signalosome component.
J Biol Chem. (2011) 286(9): 7535-7547

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